Therapeutic potential of Sertoli cells in vivo: alleviation of acute inflammation and improvement of sperm quality
Therapeutic potential of Sertoli cells in vivo: alleviation of acute inflammation and improvement of sperm quality
Blog Article
Abstract Background Inflammation-induced testicular damage is a significant contributing factor to the increasing incidence of OCTOPUS: operation control system for task optimization and job parallelization via a user-optimal scheduler infertility.Traditional treatments during the inflammatory phase often fail to achieve the desired fertility outcomes, necessitating innovative interventions such as cell therapy.Methods We explored the in vivo properties of intravenously administered Sertoli cells (SCs) in an acute lipopolysaccharide (LPS)-induced inflammatory mouse model.Infiltrating and resident myeloid cell phenotypes were assessed using flow cytometry.The impact of SC administration on testis morphology and germ cell quality was evaluated using computer-assisted sperm analysis (CASA) and immunohistochemistry.
Results SCs demonstrated a distinctive migration pattern, importantly they preferentially concentrated in the testes and liver.SC application significantly reduced neutrophil infiltration as well as preserved the resident macrophage subpopulations.SCs upregulated Identification of Specific IgE Antibodies and Asthma Control Interaction and Association Using Cluster Analysis in a Bulgarian Asthmatic Children Cohort MerTK expression in both interstitial and peritubular macrophages.Applied SC treatment exhibited protective effects on sperm including their motility and kinematic parameters, and maintained the physiological testicular morphology.Conclusion Our study provides compelling evidence of the therapeutic efficacy of SC transplantation in alleviating acute inflammation-induced testicular damage.
These findings contribute to the expanding knowledge on the potential applications of cell-based therapies for addressing reproductive health challenges and offer a promising approach for targeted interventions in male infertility.